Beautiful work
and
great results
We are committed to improving the health and quality of life of people who use drugs. We have been doing this all over the world for more than 30 years.
Our current projects
Drug use during sex can give people pleasure. However, there are situations in which risks may arise. Mainline sees this, among other things, in chemsex – a scene where men who have sex with men use drugs during sex. But...
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Mainline researches a new designer drug called alpha, street name Flakka, for care needs, prevention, harm reduction, and support for care and community service
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Sewage analyses in Zwolle show that 3-MMC use is high. Mainline is conducting a Quickscan to gain insight into usage.
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Trimbos and Mainline examine the extent and health of people with high-risk opioid use and high-risk crack cocaine use in the Netherlands.
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Mainline works with the Ghana West-Africa program to combat AIDS and STI (WAPCAS) and to help kick start harm reduction in Ghana.
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Youth between 15 - 35 years account for 51% of new HIV infections in Kenya. In particular, youth with intersecting vulnerabilities and who live under challenging socio-economic circumstances are at risk.
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The war in Ukraine has also heavily impacted the people who use drugs. Mainline is developing a community mental health response.
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Mainline is a partner in the Love Alliance programme. The Love Alliance brings together organisations led by communities most affected by HIV and AIDS in Burkina Faso, Burundi, Egypt, Kenya, Morocco, Mozambique, Nigeria, South Africa, Uganda, Zimbabwe. A database of...
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Did Mainline become a supplier? Yes: a supplier of technical advice for the Global Fund. Harm reduction organisations and networks of people who use drugs across the world can now request a Mainline training or capacity building. Read more about...
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This project in Recife, Brazil, aims to expand harm reduction and HIV care and support for young people who use crack cocaine.
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Along with the International Drug Policy Consortium and Health[e]Foundation, Mainline helped to develop an e-learning about decriminalisation. This free online course supports partners worldwide, equipping them to advocate for the end of criminalising approaches to drug use and personal possession....
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Our completed projects

Mainline investigated best practices in different countries in the field of harm reduction interventions for people who use stimulants. stimulants and interventions Most harm reduction interventions are currently financed from funds for HIV control. In practice, this means that harm...
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In this project partners across Europe work to improve (harm reduction) services access for vulnerable migrants who use drugs in the EU.
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Some of the underage refugees in The Netherlands disappear from the radar after the age of 18. Mainline tries to reach these young people and improve access to harm reduction services for them.
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Mainline works with Skoun in Lebanon to innovate harm reduction responses. Mainline offers blended learning to Skoun team members.
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Mainline provided recommendations for improving harm reduction interventions and services in Karachi, Pakistan
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OUT Well-being is a South African NGO that provides stigma-free HIV and other health services to gay, bisexual, and MSM communities. Together with the OUT field team, Mainline will pilot a community-led assessment to gather information on how best to...
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Mainline will work together with AFEW Kyrgyzstan in developing a new online and on-site outreach strategy to reach people who use new psychoactive substances, such as alpha. This designer drug is very popular in Kyrgyzstan and is commonly injected. Outreach...
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Mainline will work alongside Best Shelter to improve and upscale their mental health responses in a community-based harm reduction programme.
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Iran is renowned for its harm reduction programme. It was one of the first countries in this geographical region to adopt a harm reduction approach. Government supports and funds the programme. But the drug scene in Iran has changed over...
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Harm reduction is new in Zambia. Mainline was asked to estimate how many people inject drugs in the country and to map the already existing harm reduction and HIV services for people who use drugs. Based on this information, we...
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Mainline have been asked to assess the drug scene in five provinces in Zimbabwe. A team of three researchers worked in close collaboration with the Zimbabwe Civil Liberties Drug Network throughout 2022. The goal: to gain an insight into which...
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Harm reduction approaches are rarely applied in a recreational sports setting. And why would we - sport equals health, right? Not always. Research shows that the use of performance and image-enhancing drugs (PIEDs) is quite common in various recreational sport...
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In 2021 and 2022, SCDI in Vietnam and Mainline can continue to strengthen and expand the available harm reduction offer for people who use meth-amphetamines. After establishing the regional field lab in 2019 and 2020 we now have the opportunity...
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A round of community consultations by and for people who use drugs is currently being organised in Nepal. The goal is to identify key priorities that need to be taken up in the next Global Fund grant. Mainline offers technical...
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Mainline was asked to review the current harm reduction programmes in Nepal from the perspective of women who inject drugs. Based on interviews with women we formulated recommendations to improve service delivery.
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Everyone deserves a second chance in life. But how can you best support people who were just released from prison? And what level of additional support does a person who uses drugs need in this process?
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