Combining coke

Alcohol and Coke

Alcohol is a depressant, while cocaine is a stimulant. When combined, these substances create a conflicting effect. Cocaine’s stimulating effect masks the sensation of drunkenness. Conversely, alcohol consumption can increase the craving for cocaine to counteract its depressant effects, raising the risk of overdosing on both substances.

The combination of alcohol and cocaine can also lead to boundary-pushing behaviour. Alcohol lowers inhibitions, and coke increases confidence. Since the user does not feel as drunk and overestimates their abilities, participating in activities like driving becomes significantly more dangerous.

Additionally, combining cocaine and alcohol produces a new substance in the body called cocaethylene, which has vasoconstrictive effects like cocaine and increases heart rate. The combination poses a greater risk due to the combined stress on the cardiovascular system. The increased heart rate demands more oxygen, while the dual vasoconstrictive effects reduce oxygen supply, raising the likelihood of heart attacks and arrhythmias.

Opiates and Coke

Opiates like heroin and methadone have a depressant effect, which competes with the stimulant effect of cocaine. Cocaine’s effects wear off much faster than heroin’s, so careful dosing of heroin is essential to avoid overdose.

Experienced users sometimes inject a cocktail of coke and heroin (speedball). This creates a brief high from the coke followed by a softer landing on a heroin cushion, preventing the harsh comedown from cocaine alone. This method requires precision in dosing and understanding one’s limits to avoid the high risk of overdose.

Base coke users also often use heroin as a dampener to slow down the coke rush. For polydrug users with opiate dependence, this method can offer some respite. When using heroin to dampen the effects, smoking (not injecting) is preferred to reduce overdose risk.

Benzodiazepines and Coke 

Combining benzodiazepines (sleeping and tranquilizing medications like Valium, Seresta, or temazepam) with cocaine creates a competing effect, increasing the risk of overdose. Benzodiazepines also have a much longer duration than coke.

Users sometimes take benzodiazepines to calm down or to sleep after using coke. Knowledge of the different benzodiazepines is essential, as their effects vary. Since benzodiazepines are often taken orally, it can take half an hour to an hour to feel their effects, leading to potential overconsumption out of impatience.

Another risk with benzodiazepine use is dependence, which can develop after just two or three weeks of intensive use.

xtc and coke

Both ecstasy (XTC) and cocaine are stimulants. Their combined effect can make you feel more energized and able to party longer, but also leads to quicker exhaustion. This combination can significantly increase adrenaline release, raising blood pressure and heart rate, putting extra strain on the cardiovascular system.

The combined use of coke and XTC heavily impacts serotonin and dopamine levels, potentially causing confusion, psychotic symptoms, and dangerously high serotonin concentrations in the brain. Additionally, cocaine inhibits the breakdown of XTC in the liver, increasing the risk of negative effects on the brain (such as impaired memory, concentration, and mood).

Lastly, cocaine can diminish the “love effect” of XTC, possibly leading to increased XTC consumption.

cannabis and coke

The combination of cannabis (hashish and marijuana) and cocaine has a competing effect. A joint can help calm things down, and cannabis stimulates appetite. After an intense period of base coke use, the hunger induced by cannabis can be beneficial.

However, if you are already paranoid from heavy coke use, strong marijuana can exacerbate this paranoia. Like coke, THC (the active ingredient in cannabis) can trigger paranoia, making you more anxious and restless. Dutch marijuana often has high THC levels.

If paranoia is an issue, it is better to calm down naturally or choose a strain with lower THC and higher CBD (cannabidiol) content. CBD has calming properties and can mitigate THC’s paranoia effects. Foreign or outdoor-grown cannabis often has less THC. Foreign hashish usually contains higher CBD percentages.

Erectile Stimulants and Coke

Low doses of cocaine generally stimulate the ability to achieve an erection, but chronic use or higher doses can lead to erectile dysfunction. Erectile stimulants like Viagra, Kamagra, or Cialis are sometimes used to counteract this.

Combining cocaine with erectile pills poses risks, as cocaine raises blood pressure and narrows blood vessels, conflicting with the vasodilating and blood pressure-lowering effects of these pills. The unpredictable interaction between these effects can strain the heart, leading to cardiac issues.

Furthermore, both substances can influence each other’s breakdown in the liver, leading to dangerously high concentrations in the blood.